Oncology and Hematology: Archives

SUMMARY AND COMMENT

Factor VIII Inhibition in Black Hemophiliacs

• April 15, 2009
• David Green, MD, PhD

Some blacks seem to develop antibodies when exposed to replacement factor VIII from whites.

• Reviewing:
• Viel KR et al., N Engl J Med 2009 Apr 16; 360:1618

SUMMARY AND COMMENT

Laparoscopic Prostatectomy: Experience Matters

• April 14, 2009
• Robert Dreicer, MD, MS, FACP

The more practiced the surgeon, the less the likelihood of cancer recurrence.

• Reviewing:
• Vickers AJ et al., Lancet Oncol 2009 Apr 1

SUMMARY AND COMMENT

Lymph Node Biopsy in Older Patients with Breast Cancer

• April 14, 2009
• Henry Mark Kuerer, MD, PhD, FACS

A clinical model identifies low-risk patients who could be spared such evaluations.

• Reviewing:
• Chagpar AB et al., Ann Surg 2009 Mar; 249:455

SUMMARY AND COMMENT

Statins and Venous Thrombosis

• April 14, 2009
• David Green, MD, PhD

Recent studies confirm that statins lower risk for VT and suggest that the agents could aid in managing venous disease.

• Reviewing:
• Ramcharan AS et al., J Thromb Haemost 2009 Apr; 7:514 Sørensen HT et al., J Thromb Haemost 2009 Apr; 7:521 Cushman M., J Thromb Haemost 2009 Apr; 7:511

SUMMARY AND COMMENT

Are Disseminated Tumor Cells Prognostic in Prostate Cancer?

• April 7, 2009
• Robert Dreicer, MD, MS, FACP

Cytokeratin-positive cells detected postoperatively in bone marrow conferred excess risk for subsequent metastases.

• Reviewing:
• Weckermann D et al., J Clin Oncol 2009 Apr 1; 27:1549 Scher HI and Pantel K., J Clin Oncol 2009 Apr 1; 27:1531

SUMMARY AND COMMENT

Tibolone for Menopausal Symptoms in Breast Cancer Survivors

• April 7, 2009
• William J. Gradishar, MD

Significantly more tibolone-treated patients than placebo-treated patients experienced disease recurrence.

• Reviewing:
• Kenemans P et al., Lancet Oncol 2009 Feb; 10:135

SUMMARY AND COMMENT

The Effect of Food on Lapatinib Bioavailability

• April 7, 2009
• William J. Gradishar, MD

When administered with food, lapatinib bioavailability was substantially higher than when given to fasted patients.

• Reviewing:
• Koch KM et al., J Clin Oncol 2009 Mar 10; 27:1191

SUMMARY AND COMMENT

Lepirudin: Finding the Right Dose

• April 7, 2009
• David Green, MD, PhD

A new algorithm seemed to provide efficacious and safe dosing for patients with heparin-induced thrombocytopenia.

• Reviewing:
• Tschudi M et al., Blood 2009 Mar 12; 113:2402

SUMMARY AND COMMENT

How Well Do Breast Cancer Patients Adhere to Adjuvant Therapy?

• March 31, 2009
• William J. Gradishar, MD

Patient-reported adherence to tamoxifen and anastrozole was significantly inflated.

• Reviewing:
• Ziller V et al., Ann Oncol 2009 Mar; 20:431

SUMMARY AND COMMENT

How Disparate Is Front-Line Management of Follicular Lymphoma?

• March 31, 2009
• Michael E. Williams, MD

Therapeutic approaches vary widely in U.S. academic and community practices.

• Reviewing:
• Friedberg JW et al., J Clin Oncol 2009 Mar 10; 27:1202