Oncology and Hematology: Archives

SUMMARY AND COMMENT

Oral Hypoglycemics for Breast Cancer?

• August 11, 2009
• William J. Gradishar, MD

Diabetic patients who received metformin plus neoadjuvant chemotherapy achieved higher pathologic complete response rates than those who received chemotherapy alone.

• Reviewing:
• Jiralerspong S et al., J Clin Oncol 2009 Jul 10; 27:3297 Goodwin PJ et al., J Clin Oncol 2009 Jul 10; 27:3271

SUMMARY AND COMMENT

Racial Disparities in Breast Cancer

• August 11, 2009
• William J. Gradishar, MD

Outcomes for blacks are worse than for whites, but the reasons remain unclear.

• Reviewing:
• Albain KS et al., J Natl Cancer Inst 2009 Jul 15; 101:984 Menashe I et al., J Natl Cancer Inst 2009 Jul 15; 101:993

SUMMARY AND COMMENT

Soluble Thrombomodulin: A Marker for Warfarin-Induced Bleeding?

• August 11, 2009
• David Green, MD, PhD

Excess levels of sTM were associated with bleeding complications but not with cardiovascular events or mortality.

• Reviewing:
• Lind M et al., Arch Intern Med 2009 Jul 13; 169:1210

SUMMARY AND COMMENT

Olaparib for Cancers Associated with BRCA Mutations

• August 4, 2009
• Virginia Kaklamani, MD, DSc

The poly(adenosine diphosphate ribose) polymerase inhibitor olaparib showed antitumor activity in patients with BRCA1- and BRCA2-associated malignancies.

• Reviewing:
• Fong PC et al., N Engl J Med 2009 Jul 9; 361:123 Iglehart JD and Silver DP., N Engl J Med 2009 Jul 9; 361:189

SUMMARY AND COMMENT

Dyskeratosis Congenita and Cancer

• August 4, 2009
• David Green, MD, PhD

Patients with DC were predisposed to squamous cell cancers.

• Reviewing:
• Alter BP et al., Blood 2009 Jun 25; 113:6549 Nichols KE and Bessler M., Blood 2009 Jun 25; 113:6502

SUMMARY AND COMMENT

Leukemic Subterfuge

• July 29, 2009
• Michael E. Williams, MD

Loss of the graft-versus-leukemia HLA surface-antigen target on leukemic cells led to relapse after allotransplantation for acute myeloid leukemia.

• Reviewing:
• Vago L et al., N Engl J Med 2009 Jul 30; 361:478 Barrett J and Blazar BR., N Engl J Med 2009 Jul 30; 361:524

SUMMARY AND COMMENT

Pathogenesis of Granulosa-Cell Tumors of the Ovaries

• July 28, 2009
• Virginia Kaklamani, MD, DSc

Mutation of FOXL2 might be a driver of adult-type GCTs.

• Reviewing:
• Shah SP et al., N Engl J Med 2009 Jun 25; 360:2719 Shendure J and Stewart CJ., N Engl J Med 2009 Jun 25; 360:2781

SUMMARY AND COMMENT

Adjuvant Radiotherapy for pT3 Prostate Cancer

• July 28, 2009
• Robert Dreicer, MD, MS, FACP

In patients with undetectable PSA values after prostatectomy, radiotherapy reduced risk for biological progression.

• Reviewing:
• Wiegel T et al., J Clin Oncol 2009 Jun 20; 27:2924

SUMMARY AND COMMENT

A Model for Chuvash Polycythemia

• July 28, 2009
• David Green, MD, PhD

Main features of the disease are replicated in a novel mutant zebrafish model.

• Reviewing:
• van Rooijen E et al., Blood 2009 Jun 18; 113:6449

SUMMARY AND COMMENT

Antibiotic Therapy in Gastric Marginal Zone B-Cell Lymphoma

• July 28, 2009
• Michael E. Williams, MD

Most patients with mucosa-associated lymphoid tissue subtype disease achieved durable remissions after eradication of Helicobacter pylori infection.

• Reviewing:
• Stathis A et al., Ann Oncol 2009 Jun; 20:1086