Oncology and Hematology: Archives

SUMMARY AND COMMENT

Can Anthracycline Response Be Predicted from HER2 and TOP2A Status of Breast Tumors?

• October 6, 2009
• William J. Gradishar, MD

The predictive value of these genetic markers remains unclear.

• Reviewing:
• Tubbs R et al., J Clin Oncol 2009 Aug 20; 27:3881 Pritchard KI., J Clin Oncol 2009 Aug 20; 27:3875

SUMMARY AND COMMENT

Palliative Care for Cancer PatientsFree

• October 6, 2009
• William J. Gradishar, MD

Interventions improved quality of life and mood.

• Reviewing:
• Bakitas M et al., JAMA 2009 Aug 19; 302:741

SUMMARY AND COMMENT

Bortezomib for Systemic Amyloidosis

• September 29, 2009
• David Green, MD, PhD

Overall response was achieved by 50% of patients.

• Reviewing:
• Reece DE et al., Blood 2009 Aug 20; 114:1489

SUMMARY AND COMMENT

Cranial Irradiation in Childhood Leukemia: An Update

• September 29, 2009
• Michael G. Douvas, MD

More evidence that omission of irradiation is associated with low rates of central nervous system recurrence

• Reviewing:
• Veerman AJ et al., Lancet Oncol 2009 Sep 9

SUMMARY AND COMMENT

Is Venous Thromboembolism a Risk Factor for Arterial Events?

• September 22, 2009
• David Green, MD, PhD

Myocardial infarction and stroke were observed in patients with unprovoked pulmonary embolisms.

• Reviewing:
• Klok FA et al., Blood 2009 Aug 20; 114:1484

SUMMARY AND COMMENT

Clodronate for Prostate Cancer: An Update

• September 22, 2009
• Robert Dreicer, MD, MS, FACP

Long-term results revealed an overall survival benefit for men with metastatic, but not locally advanced, disease.

• Reviewing:
• Dearnaley DP et al., Lancet Oncol 2009 Sep; 10:872

SUMMARY AND COMMENT

Postinduction Monitoring of Acute Promyelocytic Leukemia

• September 22, 2009
• Michael E. Williams, MD

Minimal residual disease status predicted relapse-free survival in APL patients.

• Reviewing:
• Grimwade D et al., J Clin Oncol 2009 Aug 1; 27:3650

SUMMARY AND COMMENT

Prostate Cancer Mortality After Radical Prostatectomy

• September 22, 2009
• Robert Dreicer, MD, MS, FACP

Predicting disease-specific mortality on the basis of standard clinical parameters is still difficult.

• Reviewing:
• Stephenson AJ et al., J Clin Oncol 2009 Sep 10; 27:4300

SUMMARY AND COMMENT

Should Breast Cancer Survivors with Lymphedema Avoid Strength Training?

• September 15, 2009
• Henry Mark Kuerer, MD, PhD, FACS

Weight lifting improved upper-body strength without exacerbating lymphedema.

• Reviewing:
• Schmitz KH et al., N Engl J Med 2009 Aug 13; 361:664

SUMMARY AND COMMENT

Isolated Tumor Cells and Micrometastases in Breast Cancer

• September 15, 2009
• Henry Mark Kuerer, MD, PhD, FACS

Disease-free survival was diminished in patients with ITCs or micrometastases who did not receive systemic adjuvant therapy.

• Reviewing:
• de Boer M et al., N Engl J Med 2009 Aug 13; 361:653