A Novel Erythropoietin Receptor Agonist for Red Cell Aplasia
SUMMARY AND COMMENT
Hemoglobin levels improved after treatment in patients who had antierythropoietin antibodies.
Reviewing:
Macdougall IC et al., N Engl J Med 2009 Nov 5; 361:1848
MicroRNA Expression in Hepatocellular Cancer
SUMMARY AND COMMENT
Low expression of miR-26 seemed to affect survival and predict response to interferon.
Reviewing:
Ji J et al., N Engl J Med 2009 Oct 8; 361:1437
Omitting Radiation for Patients with DCIS
SUMMARY AND COMMENT
Local tumor excision alone yielded acceptably low rates of local recurrence in patients with low- and intermediate-grade DCIS.
Reviewing:
Hughes LL et al., J Clin Oncol 2009 Oct 13
Preventing Oral Mucositis in Cancer Treatment
SUMMARY AND COMMENT
Recombinant human intestinal trefoil factor produced encouraging results.
Reviewing:
Peterson DE et al., J Clin Oncol 2009 Sep 10; 27:4333
Sorafenib for Metastatic Renal Cell Cancer
SUMMARY AND COMMENT
Sorafenib had limited activity in patients with sunitinib-refractory disease.
Reviewing:
Di Lorenzo G et al., J Clin Oncol 2009 Sep 20; 27:4469
CYP2D6 Polymorphisms and Response to Tamoxifen
SUMMARY AND COMMENT
October 27, 2009
Virginia Kaklamani, MD, DSc
Breast cancer patients with genotypes corresponding to normal CYP2D6 enzyme activity achieved better outcomes than those with diminished or no activity.
Reviewing:
Schroth W et al., JAMA 2009 Oct 7; 302:1429
Daunorubicin for Younger Adults with Acute Myeloid Leukemia
SUMMARY AND COMMENT
High-dose daunorubicin improved complete response rates in patients aged 60 and younger and survival in those younger than 50.
Reviewing:
Fernandez HF et al., N Engl J Med 2009 Sep 24; 361:1249
Daunorubicin for Older Adults with Acute Myeloid Leukemia
SUMMARY AND COMMENT
High-dose daunorubicin improved complete response rates in patients aged 60 and older but did not improve survival overall.
Reviewing:
Löwenberg B et al., N Engl J Med 2009 Sep 24; 361:1235
Dombret H and Gardin C., N Engl J Med 2009 Sep 24; 361:1301
Erythropoietin for Myelodysplastic Syndromes
SUMMARY AND COMMENT
Correction of anemia was safe and improved quality of life.
Reviewing:
Greenberg PL et al., Blood 2009 Sep 17; 114:2393
Androgens, Telomerase, and Aplastic Anemia
SUMMARY AND COMMENT
Investigators uncovered a potential mechanism for androgen efficacy in aplastic anemia.
Reviewing:
Calado RT et al., Blood 2009 Sep 10; 114:2236