Prostate Cancer Screening: Still No Mortality Benefit
SUMMARY AND COMMENT
Results after 13 years of follow-up in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial confirmed earlier findings.
Reviewing:
Andriole GL et al., J Natl Cancer Inst 2012 Jan 18; 104:125
Marrow Fibrosis at Diagnosis Affects Outcome of Polycythemia Vera
SUMMARY AND COMMENT
PV patients with fibrosis were less likely than those without fibrosis to develop thrombosis but more likely to have splenomegaly and develop myelofibrosis.
Reviewing:
Barbui T et al., Blood 2012 Jan 13
Preventing Catheter Thrombosis During Percutaneous Coronary Interventions
SUMMARY AND COMMENT
Heparin was more effective than fondaparinux at inhibiting clotting induced by the contact activation pathway.
Reviewing:
Yau JW et al., Blood 2011 Dec 15; 118:6667
Thigh-Length vs. Below-Knee Compression Stockings
SUMMARY AND COMMENT
Prevention of postthrombotic syndrome was similar with both types of stockings in patients with venous thrombosis, but adverse effects were less common with below-knee stockings.
Reviewing:
Prandoni P et al., Blood 2011 Dec 16
Early-Stage Hodgkin Lymphoma: New Lessons from an Old Study
SUMMARY AND COMMENT
Overall survival was improved for patients treated with ABVD chemotherapy versus subtotal nodal irradiation.
Reviewing:
Meyer RM et al., N Engl J Med 2011 Dec 11
Straus DJ., N Engl J Med 2011 Dec 11
Report from the 53rd American Society of Hematology Annual Meeting and Exposition — Part 2: Malignant Hematology
MEETING REPORT
The latest research in hematologic malignancies
Bevacizumab for Breast Cancer: What's Next?
SUMMARY AND COMMENT
Adding bevacizumab to neoadjuvant chemotherapy raised pathologic complete response rates, but questions remain.
Reviewing:
von Minckwitz G et al., N Engl J Med 2012 Jan 26; 366:299
Bear HD et al., N Engl J Med 2012 Jan 26; 366:310
Montero AJ and Vogel C., N Engl J Med 2012 Jan 26; 366:374
Adjuvant Radiation Therapy for Breast Cancer Affects Coronary Arteries
SUMMARY AND COMMENT
Stenosis occurred in certain regions of the arterial tree, but contemporary RT has evolved to minimize this risk.
Reviewing:
Nilsson G et al., J Clin Oncol 2011 Dec 27
Zagar TM and Marks LB., J Clin Oncol 2011 Dec 27
Dual Antibodies Reap Benefits Against HER2-Positive Metastatic Breast Cancer
SUMMARY AND COMMENT
Adding pertuzumab to trastuzumab plus docetaxel prolonged progression-free survival without raising risk for cardiac events.
Reviewing:
Baselga J et al., N Engl J Med 2012 Jan 12; 366:109
The 2011 San Antonio Breast Cancer Symposium
MEETING REPORT
Highlights include adjuvant bisphosphonates, endocrine therapy, treatment of HER2-positive breast cancer, and genomic scores for predicting risk for recurrence of ductal carcinoma in situ.