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Search for Anemia in Oncology and Hematology
Physician-authored summaries on the latest research on anemia, editorials on anemia, and perspectives on anemia - drawn from the top medical journals.
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You searched for: anemia in Oncology and Hematology
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Plugging the Leak in Sickle Cells
- May 6, 2008
- David Green, MD, PhD
- Oncology and Hematology
Treatment with senicapoc, a Gardos-channel inhibitor, was associated with increased hemoglobin levels and attenuated cell dehydration and hemolysis in sickle cell patients.- Reviewing:
- Ataga KI et al., Blood 2008 Apr 15; 111:3991. Joiner CH., Blood 2008 Apr 15; 111:3918.
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Darbepoetin for Anemia of Cancer
- March 18, 2008
- Barbara A. Murphy, MD
- Oncology and Hematology
In an international study, researchers failed to demonstrate a significant benefit for ESAs in patients with AoC who were not receiving myelosuppressive chemotherapy or radiotherapy.- Reviewing:
- Smith RE Jr et al., J Clin Oncol 2008 Mar 1; 26:1040.
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Treatment of Aplastic Anemia
- October 16, 2007
- David Green, MD, PhD
- Oncology and Hematology
Adding G-CSF to standard therapy (ATG plus CyA) increased the percentage of patients who responded at 6 months.- Reviewing:
- Teramura M et al., Blood 2007 Sep 15; 110:1756.
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Complete Correction of Anemia of Renal Failure Is Not Advised
- December 11, 2006
- David Green, MD, PhD
- Oncology and Hematology
Target Hb levels should not exceed 12 g/dL.- Reviewing:
- Drüeke TB et al., N Engl J Med 2006 Nov 16; 355:2071-84. Singh AK et al., N Engl J Med 2006 Nov 16; 355:2085-98.
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Erythropoietin for Myelodysplastic Syndromes
- October 20, 2009
- David Green, MD, PhD
- Oncology and Hematology
Correction of anemia was safe and improved quality of life.- Reviewing:
- Greenberg PL et al., Blood 2009 Sep 17; 114:2393.
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Androgens, Telomerase, and Aplastic Anemia
- October 20, 2009
- David Green, MD, PhD
- Oncology and Hematology
Investigators uncovered a potential mechanism for androgen efficacy in aplastic anemia.- Reviewing:
- Calado RT et al., Blood 2009 Sep 10; 114:2236.
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Azacitidine Dosing for Myelodysplastic Syndromes
- April 28, 2009
- Michael E. Williams, MD
- Oncology and Hematology
Alternative schedules provided outcomes similar to those achieved with the standard regimen.- Reviewing:
- Lyons RM et al., J Clin Oncol 2009 Apr 10; 27:1850.
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Azacitidine for High-Risk Myelodysplastic Syndromes
- March 24, 2009
- Michael E. Williams, MD
- Oncology and Hematology
Patients who received azacitidine achieved longer overall survival than those who received conventional care.- Reviewing:
- Fenaux P et al., Lancet Oncol 2009 Mar; 10:223.
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Risk Factors for Pulmonary Hypertension in Sickle Cell Patients
- July 8, 2008
- David Green, MD, PhD
- Oncology and Hematology
Genetic variants in SCD patients were associated with PH.- Reviewing:
- Ashley-Koch AE et al., Blood 2008 Jun 15; 111:5721.
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Erythropoietin in Critical Care Patients Free
- September 5, 2007
- David Green, MD, PhD
- Oncology and Hematology
Among all ICU patients, need for transfusion did not change when epoetin was administered; among trauma patients, epoetin increased the 140-day survival rate.- Reviewing:
- Corwin HL et al., N Engl J Med 2007 Sep 6; 357:965-76.
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Hydroxyurea for Sickle Cell Disease: Coming of Age
- May 6, 2008
- David Green, MD, PhD
- Oncology and Hematology
HU is effective but underused in U.S. patients with SCD.- Reviewing:
- Brawley OW et al., Ann Intern Med 2008 May 5;:
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Venous Thrombosis in Patients with Sickle Cell Trait
- August 21, 2007
- David Green, MD, PhD
- Oncology and Hematology
In a case-control study, sickle cell trait was twice as likely to occur in VTE patients as in controls.- Reviewing:
- Austin H et al., Blood 2007 Aug 1; 110:908-12.
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Impaired Renal Function in Sickle Cell Patients
- April 30, 2007
- David Green, MD, PhD
- Oncology and Hematology
Young sickle cell patients without overt kidney disease exhibited significantly increased creatinine clearance and albumin excretion rates compared with age-matched controls.- Reviewing:
- Thompson J et al., Arch Intern Med 2007 Apr 9; 167:701-8.
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A Novel Erythropoietin Receptor Agonist for Red Cell Aplasia
- November 4, 2009
- David Green, MD, PhD
- Oncology and Hematology
Hemoglobin levels improved after treatment in patients who had antierythropoietin antibodies.- Reviewing:
- Macdougall IC et al., N Engl J Med 2009 Nov 5; 361:1848.
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Assessing Risk in Follicular Lymphoma
- September 1, 2009
- Michael E. Williams, MD
- Oncology and Hematology
An update to the FL International Prognostic Index (FLIPI) for newly diagnosed disease- Reviewing:
- Federico M et al., J Clin Oncol 2009 Aug 3;:
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Hemolytic Uremic Syndrome
- August 25, 2009
- David Green, MD, PhD
- Oncology and Hematology
Mutations that impair thrombomodulin function occur in nearly 5% of patients with atypical HUS.- Reviewing:
- Delvaeye M et al., N Engl J Med 2009 Jul 23; 361:345.
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Dyskeratosis Congenita and Cancer
- August 4, 2009
- David Green, MD, PhD
- Oncology and Hematology
Patients with DC were predisposed to squamous cell cancers.- Reviewing:
- Alter BP et al., Blood 2009 Jun 25; 113:6549. Nichols KE and Bessler M., Blood 2009 Jun 25; 113:6502.
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A Model for Chuvash Polycythemia
- July 28, 2009
- David Green, MD, PhD
- Oncology and Hematology
Main features of the disease are replicated in a novel mutant zebrafish model.- Reviewing:
- van Rooijen E et al., Blood 2009 Jun 18; 113:6449.
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Rituximab and Progressive Multifocal Leukoencephalopathy
- June 30, 2009
- Michael E. Williams, MD
- Oncology and Hematology
New evidence of an association supports the need for caution among clinicians who prescribe rituximab.- Reviewing:
- Carson KR et al., Blood 2009 May 14; 113:4834.
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Genotype-Guided Warfarin Dosing: Is It Cost-Effective?
- February 10, 2009
- David Green, MD, PhD
- Oncology and Hematology
Costs would be above society’s willingness-to-pay threshold unless the approach could prevent at least a third of bleeding events in patients with nonvalvular atrial fibrillation.- Reviewing:
- Eckman MH et al., Ann Intern Med 2009 Jan 20; 150:73.
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