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Oncology and Hematology
Your source for the best literature from the fields of oncology and hematology, along with clinical commentary to put it into perspective.
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Featured Article
SUMMARY AND COMMENT
Imatinib Dosing for Patients with Chronic-Phase CML
- February 9, 2010
- Michael E. Williams, MD
Higher dosing was associated with more early-onset responses than standard dosing, but response rates at each dose were similar after 1 year of therapy.
- Reviewing:
- Cortes JE et al. J Clin Oncol 2010 Jan 20; 28:424
Special Notice
News from the 2009 San Antonio Breast Cancer Symposium
The Editor-in-Chief of Journal Watch Oncology and Hematology discusses key findings presented at the 2009 San Antonio Breast Cancer Symposium.
Recent Oncology and Hematology Articles
SUMMARY AND COMMENT
Nilotinib as Initial Therapy for Patients with CML
- February 9, 2010
- Michael E. Williams, MD
In two studies, treatment with nilotinib resulted in rapid induction and high rates of remission in patients with chronic-phase CML.
- Reviewing:
- Cortes JE et al. J Clin Oncol 2010 Jan 20; 28:392
MEETING REPORT
Meeting Report: The 2009 San Antonio Breast Cancer Symposium
- February 2, 2010
- William J. Gradishar, MD
Understanding the role of antiangiogenesis therapies in metastatic disease and optimizing treatment of patients with HER2-positive disease were common themes.
SUMMARY AND COMMENT
Dasatinib as Initial Therapy for Patients with CML
- February 2, 2010
- Michael E. Williams, MD
Dasatinib was associated with rapid hematologic and molecular responses in patients with newly diagnosed chronic-phase CML.
- Reviewing:
- Cortes JE et al. J Clin Oncol 2010 Jan 20; 28:398
SUMMARY AND COMMENT
Polypectomy and Anticoagulant Therapy
- February 2, 2010
- David Green, MD, PhD
Use caution when resuming anticoagulants after procedures.
- Reviewing:
- Witt DM et al. J Thromb Haemost 2009 Dec; 7:1982
MEETING REPORT
Report from the 51st American Society of Hematology Annual Meeting and Exposition: Thrombotic Disease
- January 26, 2010
- David Green, MD, PhD
A summary of some of the latest findings in thrombosis research
SUMMARY AND COMMENT
What to Do with a Pulmonary Nodule?
- January 26, 2010
- Lin-Chi Chen, MD, PhD
Serial volumetric CT scanning and analysis might help differentiate cancerous from benign nodules.
- Reviewing:
- van Klaveren RJ et al. N Engl J Med 2009 Dec 3; 361:2221
SUMMARY AND COMMENT
Managing Hot Flushes in Men Who Receive Androgen-Deprivation Therapy
- January 19, 2010
- Robert Dreicer, MD, MS, FACP
Hormonal treatments were more effective than venlafaxine in reducing hot-flush frequency and severity.
- Reviewing:
- Irani J et al. Lancet Oncol 2009 Dec 7
SUMMARY AND COMMENT
Toxicity with Androgen-Deprivation Therapy: The Plot Thickens
- January 19, 2010
- Robert Dreicer, MD, MS, FACP
Men who were treated with ADT for local and regional prostate cancer had excess risk for diabetes and cardiovascular disease.
- Reviewing:
- Keating NL et al. J Natl Cancer Inst 2010 Jan 6; 102:39
MEETING REPORT
Report From the 51st American Society of Hematology Annual Meeting and Exposition: Malignant Hematology
- January 12, 2010
- Michael E. Williams, MD
The latest reports on treatment of B-cell lymphomas and high- and low-risk Hodgkin lymphomas
SUMMARY AND COMMENT
Non–Cisplatin-Containing Chemotherapy in Patients with Advanced Urothelial Cancer
- January 12, 2010
- Robert Dreicer, MD, MS, FACP
Treatment benefits did not outweigh toxicity risks in patients with poor renal function and performance status.
- Reviewing:
- De Santis M et al. J Clin Oncol 2009 Nov 20; 27:5634
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Bevacizumab Failure in Recurrent Glioblastoma
- January 12, 2010
- By Andrew D. Norden, MD, MPH
- Neurology
In this small, retrospective analysis of patients with recurrent glioblastoma treated with bevacizumab, a nonenhancing pattern of tumor relapse on MRI was common and portended an extremely poor prognosis.
- Reviewing:
- Neurology 2009 Oct 13; 73:1200
SUMMARY AND COMMENT
More on HIV Infection and Cancer Risk
- January 15, 2010
- By Carlos del Rio, MD
- HIV/AIDS Clinical Care
Untreated HIV infection and the presence of immunosuppression were each associated with the development of cancer among HIV-infected patients in a French cohort.
- Reviewing:
- Clin Infect Dis 2009 Oct 1; 49:1109
YEAR IN REVIEW
PSA for Prostate Cancer Screening: Controversy Continues in 2009Free
- December 31, 2009
- By Thomas L. Schwenk, MD
- General Medicine
Does PSA screening save lives, lead to unnecessary treatment, or both?
SUMMARY AND COMMENT
Extracolonic Tumors in Patients with MUTYH-Associated Polyposis
- January 8, 2010
- By Douglas K. Rex, MD
- Gastroenterology
Data from a retrospective analysis support interval upper-GI endoscopy for these patients. CME
- Reviewing:
- Gastroenterology 2009 Dec; 137:1976
Journal Watch Oncology and Hematology summarizes important medical journal articles about a wide variety of oncology and hematology topics, including leukemia, anemia, lymphoma, thrombosis, and hemochromatosis.
