- Home>
- Specialties>
- Oncology and Hematology
Oncology and Hematology
Your source for the best literature from the fields of oncology and hematology, along with clinical commentary to put it into perspective.
Featured Article
SUMMARY AND COMMENT
A Novel Erythropoietin Receptor Agonist for Red Cell Aplasia
- November 4, 2009
- David Green, MD, PhD
Hemoglobin levels improved after treatment in patients who had antierythropoietin antibodies.
- Reviewing:
- Macdougall IC et al. N Engl J Med 2009 Nov 5; 361:1848
Recent Oncology and Hematology Articles
SUMMARY AND COMMENT
Omitting Radiation for Patients with DCIS
- November 3, 2009
- Henry Mark Kuerer, MD, PhD, FACS
Local tumor excision alone yielded acceptably low rates of local recurrence in patients with low- and intermediate-grade DCIS.
- Reviewing:
- Hughes LL et al. J Clin Oncol 2009 Oct 13
SUMMARY AND COMMENT
MicroRNA Expression in Hepatocellular Cancer
- November 3, 2009
- David H. Ilson, MD, PhD
Low expression of miR-26 seemed to affect survival and predict response to interferon.
- Reviewing:
- Ji J et al. N Engl J Med 2009 Oct 8; 361:1437
SUMMARY AND COMMENT
Sorafenib for Metastatic Renal Cell Cancer
- October 27, 2009
- Robert Dreicer, MD, MS, FACP
Sorafenib had limited activity in patients with sunitinib-refractory disease.
- Reviewing:
- Di Lorenzo G et al. J Clin Oncol 2009 Sep 20; 27:4469
SUMMARY AND COMMENT
Preventing Oral Mucositis in Cancer Treatment
- October 27, 2009
- Barbara A. Murphy, MD
Recombinant human intestinal trefoil factor produced encouraging results.
- Reviewing:
- Peterson DE et al. J Clin Oncol 2009 Sep 10; 27:4333
SUMMARY AND COMMENT
CYP2D6 Polymorphisms and Response to Tamoxifen
- October 27, 2009
- Virginia Kaklamani, MD, DSc
Breast cancer patients with genotypes corresponding to normal CYP2D6 enzyme activity achieved better outcomes than those with diminished or no activity.
- Reviewing:
- Schroth W et al. JAMA 2009 Oct 7; 302:1429
SUMMARY AND COMMENT
Mastectomy Instead of BCS: What Is the Role of the Surgeon's Recommendation?Free
- October 22, 2009
- Andrew M. Kaunitz, MD
- Women's Health
Reasons for mastectomy are related to surgeon's recommendation, patient's preference, and contraindications to breast-conserving surgery.
- Reviewing:
- Morrow M et al. JAMA 2009 Oct 14; 302:1551
SUMMARY AND COMMENT
Daunorubicin for Younger Adults with Acute Myeloid Leukemia
- October 20, 2009
- Michael E. Williams, MD
High-dose daunorubicin improved complete response rates in patients aged 60 and younger and survival in those younger than 50.
- Reviewing:
- Fernandez HF et al. N Engl J Med 2009 Sep 24; 361:1249
SUMMARY AND COMMENT
Daunorubicin for Older Adults with Acute Myeloid Leukemia
- October 20, 2009
- Michael E. Williams, MD
High-dose daunorubicin improved complete response rates in patients aged 60 and older but did not improve survival overall.
- Reviewing:
- Löwenberg B et al. N Engl J Med 2009 Sep 24; 361:1235
SUMMARY AND COMMENT
Erythropoietin for Myelodysplastic Syndromes
- October 20, 2009
- David Green, MD, PhD
Correction of anemia was safe and improved quality of life.
- Reviewing:
- Greenberg PL et al. Blood 2009 Sep 17; 114:2393
SUMMARY AND COMMENT
Androgens, Telomerase, and Aplastic Anemia
- October 20, 2009
- David Green, MD, PhD
Investigators uncovered a potential mechanism for androgen efficacy in aplastic anemia.
- Reviewing:
- Calado RT et al. Blood 2009 Sep 10; 114:2236
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Polymorphisms in CTLA4 Confer Susceptibility to Nonmelanoma Skin CancersFree
- September 25, 2009
- By Craig A. Elmets, MD
- Dermatology
A genetic variant that confers excess risk for autoimmune disease may also protect against nonmelanoma skin cancers.
- Reviewing:
- Cancer Res 2009 Aug 1; 69:6158
SUMMARY AND COMMENT
Warfarin for Stroke Prevention in Patients with Atrial Fibrillation
- September 16, 2009
- By Joel M. Gore, MD
- Cardiology
Results of a large observational study provide current data for accurate risk-benefit estimation.
- Reviewing:
- Ann Intern Med 2009 Sep 1; 151:297
SUMMARY AND COMMENT
Overdiagnosis in PSA Screening
- September 24, 2009
- By Allan S. Brett, MD
- General Medicine
An analysis suggests that many men have been treated unnecessarily because of PSA screening.
- Reviewing:
- J Natl Cancer Inst 2009 Aug 31
SUMMARY AND COMMENT
An Alternative to Warfarin in Patients with Atrial Fibrillation?
- September 1, 2009
- By Harlan M. Krumholz, MD, SM
- Cardiology
Compared with warfarin, low-dose dabigatran performed better with regard to safety but not efficacy, and high-dose dabigatran performed better with regard to efficacy but not safety.
- Reviewing:
- N Engl J Med 2009 Aug 30
Journal Watch Oncology and Hematology summarizes important medical journal articles about a wide variety of oncology and hematology topics, including leukemia, anemia, lymphoma, thrombosis, and hemochromatosis.
