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Oncology and Hematology
Your source for the best literature from the fields of oncology and hematology, along with clinical commentary to put it into perspective.
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Featured Article
SUMMARY AND COMMENT
Flavopiridol for High-Risk CLL
- November 17, 2009
- Michael E. Williams, MD
Heavily pretreated patients with relapsed CLL experienced good responses to the cell cycle inhibitor flavopiridol.
- Reviewing:
- Lin TS et al. J Clin Oncol 2009 Oct 13
Recent Oncology and Hematology Articles
SUMMARY AND COMMENT
Pancreatic Cancer and Gene Mutations for Lynch Syndrome
- November 13, 2009
- Stuart Sherman, MD
- Gastroenterology
Compared with the general population, families with mutations had significantly greater cancer risk.
- Reviewing:
- Kastrinos F et al. JAMA 2009 Oct 28; 302:1790
SUMMARY AND COMMENT
Open vs. Minimally Invasive Radical Prostatectomy
- November 10, 2009
- Robert Dreicer, MD, MS, FACP
Each surgical approach conferred certain advantages, but conclusions about outcomes are limited by data collection methodology.
- Reviewing:
- Hu JC et al. JAMA 2009 Oct 14; 302:1557
SUMMARY AND COMMENT
Octreotide Treatment for Neuroendocrine Tumors
- November 10, 2009
- David H. Ilson, MD, PhD
In treatment-naive patients, octreotide substantially lengthened time to tumor progression.
- Reviewing:
- Rinke A et al. J Clin Oncol 2009 Oct 1; 27:4656
SUMMARY AND COMMENT
Breast Cancer and BRCA Status in Young Women of Diverse Racial Groups
- November 10, 2009
- William J. Gradishar, MD
Frequencies of deletion mutations in BRCA1/2 genes were similar across racial groups.
- Reviewing:
- Haffty BG et al. Ann Oncol 2009 Oct; 20:1653
SUMMARY AND COMMENT
Predictors of Survival in DLBCL
- November 10, 2009
- Michael E. Williams, MD
A combination of techniques identified biomarkers that predicted survival in patients with diffuse large B-cell lymphoma.
- Reviewing:
- Copie-Bergman C et al. J Clin Oncol 2009 Sep 28
SUMMARY AND COMMENT
A Novel Erythropoietin Receptor Agonist for Red Cell Aplasia
- November 4, 2009
- David Green, MD, PhD
Hemoglobin levels improved after treatment in patients who had antierythropoietin antibodies.
- Reviewing:
- Macdougall IC et al. N Engl J Med 2009 Nov 5; 361:1848
SUMMARY AND COMMENT
Darbepoetin 
in Patients with Type 2 Diabetes, Chronic Kidney Disease, and Anemia
- November 3, 2009
- Paul S. Mueller, MD, MPH, FACP
- General Medicine
The drug provides little benefit and might cause harm.
- Reviewing:
- Pfeffer MA et al. N Engl J Med 2009 Oct 30
SUMMARY AND COMMENT
Omitting Radiation for Patients with DCIS
- November 3, 2009
- Henry Mark Kuerer, MD, PhD, FACS
Local tumor excision alone yielded acceptably low rates of local recurrence in patients with low- and intermediate-grade DCIS.
- Reviewing:
- Hughes LL et al. J Clin Oncol 2009 Oct 13
SUMMARY AND COMMENT
MicroRNA Expression in Hepatocellular Cancer
- November 3, 2009
- David H. Ilson, MD, PhD
Low expression of miR-26 seemed to affect survival and predict response to interferon.
- Reviewing:
- Ji J et al. N Engl J Med 2009 Oct 8; 361:1437
SUMMARY AND COMMENT
Sorafenib for Metastatic Renal Cell Cancer
- October 27, 2009
- Robert Dreicer, MD, MS, FACP
Sorafenib had limited activity in patients with sunitinib-refractory disease.
- Reviewing:
- Di Lorenzo G et al. J Clin Oncol 2009 Sep 20; 27:4469
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
A New Factor Xa Inhibitor Prepares for Its Close-Up
- October 7, 2009
- By Beat J. Meyer, MD
- Cardiology
Otamixaban shows promise in patients with ACS, but do we really need another intravenous anticoagulant?
- Reviewing:
- Lancet 2009 Sep 5; 374:787
SUMMARY AND COMMENT
Mastectomy Rates Are RisingFree
- October 1, 2009
- By Allan S. Brett, MD
- General Medicine
And breast-conserving surgery rates are falling — Can preoperative MRI be responsible? Interview
- Reviewing:
- J Clin Oncol 2009 Sep 1; 27:4082
SUMMARY AND COMMENT
Is Clinical Breast Examination, Added to Mammography, Worthwhile?
- October 1, 2009
- By Allan S. Brett, MD
- General Medicine
CBE was associated with 55 additional false-positives for each additional breast cancer detected.
- Reviewing:
- J Natl Cancer Inst 2009 Sep 16; 101:1236
SUMMARY AND COMMENT
Polymorphisms in CTLA4 Confer Susceptibility to Nonmelanoma Skin CancersFree
- September 25, 2009
- By Craig A. Elmets, MD
- Dermatology
A genetic variant that confers excess risk for autoimmune disease may also protect against nonmelanoma skin cancers.
- Reviewing:
- Cancer Res 2009 Aug 1; 69:6158
Journal Watch Oncology and Hematology summarizes important medical journal articles about a wide variety of oncology and hematology topics, including leukemia, anemia, lymphoma, thrombosis, and hemochromatosis.
