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Oncology and Hematology

Your source for the best literature from the fields of oncology and hematology, along with clinical commentary to put it into perspective.

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Recombinant Factor VIIa Fails to Modify Outcomes After Intracerebral Hemorrhage

  • Summary and Comment
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Less hematoma growth with rFVIIa therapy was not associated with better 90-day neurologic outcomes.

Stratifying Risk in AML

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Presence of leukemia cell mutations correlated with treatment outcomes in patients with karyotypically normal acute myelogenous leukemia.

Lapatinib for Treatment of Metastatic Brain Metastases

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This antitumor agent failed to provide a predefined CNS response, but its use was associated with volumetric reductions in target lesions.

Weekly Paclitaxel in the Adjuvant Treatment of Breast Cancer

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Frequent paclitaxel therapy, but not docetaxel therapy, benefitted women with HER2-positive or HER2-negative tumors.

Pharmacogenomics, CYP2D6, and Adjuvant Endocrine Therapy

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CYP2D6 genotype data could help tailor hormonal therapy for postmenopausal breast cancer patients.

Open Versus Laparoscopic Radical Prostatectomy

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LRP was associated with less blood loss but lower probability of continence recovery than was open prostatectomy.

Venous Thrombosis and Cancer

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Lung cancer and childhood leukemia are associated with a high incidence of venous thrombosis and its complications.

Hydroxyurea for Sickle Cell Disease: Coming of Age

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HU is effective but underused in U.S. patients with SCD.

Plugging the Leak in Sickle Cells

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Treatment with senicapoc, a Gardos-channel inhibitor, was associated with increased hemoglobin levels and attenuated cell dehydration and hemolysis in sickle cell patients.

Induction Chemotherapy and 5-FU/Cisplatin Fail to Improve Outcomes in Anal Cancer

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Both overall and disease-free survival were similar with standard therapy or with the new regimen.

Genetic Basis for QOL Differences After Radiotherapy for Prostate Cancer

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Severity of three radiotherapy side effects was evaluated in patients with known TGFB1 genotypes.

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Editor's Picks from across Journal Watch

Flat Lesions Becoming More Prevalent in the U.S.

  • Gastroenterology
  • Summary and Comment
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Recently published data have highlighted the prevalence of flat and depressed lesions in the U.S. population and risk for high-grade dysplasia and invasive cancer that is associated with these lesions.

Hormone Therapy in Breast Cancer Survivors

  • General Medicine
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Hormone therapy in this population raises risk for recurrence.

How Safe Are OCs and Menopausal Hormone Therapy After Breast Cancer?

  • Women's Health
  • Summary and Comment
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Use of the pill or hormone therapy does not seem to increase risk for a second primary breast cancer.

Probing the Genetics of Deep Venous Thrombosis

  • Cardiology
  • Summary and Comment
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In a study of data from three case-control studies, researchers identified several SNPs that may contribute to DVT risk.

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Journal Watch Oncology and Hematology summarizes important medical journal articles about a wide variety of oncology and hematology topics, including leukemia, anemia, lymphoma, thrombosis, and hemochromatosis.

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Editor-in-Chief >

William J. Gradishar, MD
William J. Gradishar, MD
Professor of Medicine, and Director of the Hematology-Medical Oncology Fellowship Training Program, Department of Medicine, Northwestern University Feinberg School of Medicine

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