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Oncology and Hematology
Your source for the best literature from the fields of oncology and hematology, along with clinical commentary to put it into perspective.
Recombinant Factor VIIa Fails to Modify Outcomes After Intracerebral Hemorrhage
- Summary and Comment
- Subscription required
Less hematoma growth with rFVIIa therapy was not associated with better 90-day neurologic outcomes.
- By David Green, MD, PhD
- May 14, 2008
- Covering N Engl J Med 2008 May 15
Stratifying Risk in AML
- Summary and Comment
- Free
Presence of leukemia cell mutations correlated with treatment outcomes in patients with karyotypically normal acute myelogenous leukemia.
- By Michael E. Williams, MD
- May 13, 2008
- Covering N Engl J Med 2008 May 1
Lapatinib for Treatment of Metastatic Brain Metastases
- Summary and Comment
- Subscription required
This antitumor agent failed to provide a predefined CNS response, but its use was associated with volumetric reductions in target lesions.
- By William J. Gradishar, MD
- May 13, 2008
- Covering J Clin Oncol 2008 Apr 20
Weekly Paclitaxel in the Adjuvant Treatment of Breast Cancer
- Summary and Comment
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Frequent paclitaxel therapy, but not docetaxel therapy, benefitted women with HER2-positive or HER2-negative tumors.
- By William J. Gradishar, MD
- May 13, 2008
- Covering N Engl J Med 2008 Apr 17
Pharmacogenomics, CYP2D6, and Adjuvant Endocrine Therapy
- Summary and Comment
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CYP2D6 genotype data could help tailor hormonal therapy for postmenopausal breast cancer patients.
- By William J. Gradishar, MD
- May 13, 2008
- Covering J Natl Cancer Inst 2008 May 7
Open Versus Laparoscopic Radical Prostatectomy
- Summary and Comment
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LRP was associated with less blood loss but lower probability of continence recovery than was open prostatectomy.
- By Robert Dreicer, MD, MS, FACP
- May 13, 2008
- Covering J Urol 2008 May
Venous Thrombosis and Cancer
- Summary and Comment
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Lung cancer and childhood leukemia are associated with a high incidence of venous thrombosis and its complications.
- By David Green, MD, PhD
- May 13, 2008
- Covering J Thromb Haemost 2008 Apr
Hydroxyurea for Sickle Cell Disease: Coming of Age
- Summary and Comment
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HU is effective but underused in U.S. patients with SCD.
- By David Green, MD, PhD
- May 6, 2008
- Covering Ann Intern Med 2008 May 5
Plugging the Leak in Sickle Cells
- Summary and Comment
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Treatment with senicapoc, a Gardos-channel inhibitor, was associated with increased hemoglobin levels and attenuated cell dehydration and hemolysis in sickle cell patients.
- By David Green, MD, PhD
- May 6, 2008
- Covering Blood 2008 Apr 15
Induction Chemotherapy and 5-FU/Cisplatin Fail to Improve Outcomes in Anal Cancer
- Summary and Comment
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Both overall and disease-free survival were similar with standard therapy or with the new regimen.
- By David H. Ilson, MD, PhD
- May 6, 2008
- Covering JAMA 2008 Apr 23
Genetic Basis for QOL Differences After Radiotherapy for Prostate Cancer
- Summary and Comment
- Subscription required
Severity of three radiotherapy side effects was evaluated in patients with known TGFB1 genotypes.
- By Barbara A. Murphy, MD
- May 6, 2008
- Covering Int J Radiat Oncol Biol Phys 2008 Mar 1
Editor's Picks from across Journal Watch
Flat Lesions Becoming More Prevalent in the U.S.
- Gastroenterology
- Summary and Comment
- Subscription required
Recently published data have highlighted the prevalence of flat and depressed lesions in the U.S. population and risk for high-grade dysplasia and invasive cancer that is associated with these lesions.
- By Douglas K. Rex, MD
- March 21, 2008
- Covering JAMA 2008 Mar 5
Hormone Therapy in Breast Cancer Survivors
- General Medicine
- Summary and Comment
- Subscription required
Hormone therapy in this population raises risk for recurrence.
- By Allan S. Brett, MD
- April 24, 2008
- Covering J Natl Cancer Inst 2008 Apr 2
How Safe Are OCs and Menopausal Hormone Therapy After Breast Cancer?
- Women's Health
- Summary and Comment
- Subscription required
Use of the pill or hormone therapy does not seem to increase risk for a second primary breast cancer.
- By Andrew M. Kaunitz, MD
- March 20, 2008
- Covering J Clin Oncol 2008 Feb 4
Probing the Genetics of Deep Venous Thrombosis
- Cardiology
- Summary and Comment
- Subscription required
In a study of data from three case-control studies, researchers identified several SNPs that may contribute to DVT risk.
- By JoAnne M. Foody, MD
- March 19, 2008
- Covering JAMA 2008 Mar 19
Journal Watch Oncology and Hematology summarizes important medical journal articles about a wide variety of oncology and hematology topics, including leukemia, anemia, lymphoma, thrombosis, and hemochromatosis.
