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Oncology and Hematology
Your source for the best literature from the fields of oncology and hematology, along with clinical commentary to put it into perspective.
Featured Article

SUMMARY AND COMMENT
A Novel Erythropoietin Receptor Agonist for Red Cell Aplasia
- November 4, 2009
- David Green, MD, PhD
Hemoglobin levels improved after treatment in patients who had antierythropoietin antibodies.
- Reviewing:
- Macdougall IC et al. N Engl J Med 2009 Nov 5; 361:1848
Recent Oncology and Hematology Articles
SUMMARY AND COMMENT
Omitting Radiation for Patients with DCIS
- November 3, 2009
- Henry Mark Kuerer, MD, PhD, FACS
Local tumor excision alone yielded acceptably low rates of local recurrence in patients with low- and intermediate-grade DCIS.
- Reviewing:
- Hughes LL et al. J Clin Oncol 2009 Oct 13
SUMMARY AND COMMENT
MicroRNA Expression in Hepatocellular Cancer
- November 3, 2009
- David H. Ilson, MD, PhD
Low expression of miR-26 seemed to affect survival and predict response to interferon.
- Reviewing:
- Ji J et al. N Engl J Med 2009 Oct 8; 361:1437
SUMMARY AND COMMENT
Sorafenib for Metastatic Renal Cell Cancer
- October 27, 2009
- Robert Dreicer, MD, MS, FACP
Sorafenib had limited activity in patients with sunitinib-refractory disease.
- Reviewing:
- Di Lorenzo G et al. J Clin Oncol 2009 Sep 20; 27:4469
SUMMARY AND COMMENT
Preventing Oral Mucositis in Cancer Treatment
- October 27, 2009
- Barbara A. Murphy, MD
Recombinant human intestinal trefoil factor produced encouraging results.
- Reviewing:
- Peterson DE et al. J Clin Oncol 2009 Sep 10; 27:4333
SUMMARY AND COMMENT
CYP2D6 Polymorphisms and Response to Tamoxifen
- October 27, 2009
- Virginia Kaklamani, MD, DSc
Breast cancer patients with genotypes corresponding to normal CYP2D6 enzyme activity achieved better outcomes than those with diminished or no activity.
- Reviewing:
- Schroth W et al. JAMA 2009 Oct 7; 302:1429
SUMMARY AND COMMENT
Mastectomy Instead of BCS: What Is the Role of the Surgeon's Recommendation?Free
- October 22, 2009
- Andrew M. Kaunitz, MD
- Women's Health
Reasons for mastectomy are related to surgeon's recommendation, patient's preference, and contraindications to breast-conserving surgery.
- Reviewing:
- Morrow M et al. JAMA 2009 Oct 14; 302:1551
SUMMARY AND COMMENT
Daunorubicin for Younger Adults with Acute Myeloid Leukemia
- October 20, 2009
- Michael E. Williams, MD
High-dose daunorubicin improved complete response rates in patients aged 60 and younger and survival in those younger than 50.
- Reviewing:
- Fernandez HF et al. N Engl J Med 2009 Sep 24; 361:1249
SUMMARY AND COMMENT
Daunorubicin for Older Adults with Acute Myeloid Leukemia
- October 20, 2009
- Michael E. Williams, MD
High-dose daunorubicin improved complete response rates in patients aged 60 and older but did not improve survival overall.
- Reviewing:
- Löwenberg B et al. N Engl J Med 2009 Sep 24; 361:1235
SUMMARY AND COMMENT
Erythropoietin for Myelodysplastic Syndromes
- October 20, 2009
- David Green, MD, PhD
Correction of anemia was safe and improved quality of life.
- Reviewing:
- Greenberg PL et al. Blood 2009 Sep 17; 114:2393
SUMMARY AND COMMENT
Androgens, Telomerase, and Aplastic Anemia
- October 20, 2009
- David Green, MD, PhD
Investigators uncovered a potential mechanism for androgen efficacy in aplastic anemia.
- Reviewing:
- Calado RT et al. Blood 2009 Sep 10; 114:2236
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Polymorphisms in CTLA4 Confer Susceptibility to Nonmelanoma Skin CancersFree
- September 25, 2009
- By Craig A. Elmets, MD
- Dermatology
A genetic variant that confers excess risk for autoimmune disease may also protect against nonmelanoma skin cancers.
- Reviewing:
- Cancer Res 2009 Aug 1; 69:6158
SUMMARY AND COMMENT
Warfarin for Stroke Prevention in Patients with Atrial Fibrillation
- September 16, 2009
- By Joel M. Gore, MD
- Cardiology
Results of a large observational study provide current data for accurate risk-benefit estimation.
- Reviewing:
- Ann Intern Med 2009 Sep 1; 151:297
SUMMARY AND COMMENT
Overdiagnosis in PSA Screening
- September 24, 2009
- By Allan S. Brett, MD
- General Medicine
An analysis suggests that many men have been treated unnecessarily because of PSA screening.
- Reviewing:
- J Natl Cancer Inst 2009 Aug 31
SUMMARY AND COMMENT
An Alternative to Warfarin in Patients with Atrial Fibrillation?
- September 1, 2009
- By Harlan M. Krumholz, MD, SM
- Cardiology
Compared with warfarin, low-dose dabigatran performed better with regard to safety but not efficacy, and high-dose dabigatran performed better with regard to efficacy but not safety.
- Reviewing:
- N Engl J Med 2009 Aug 30
Journal Watch Oncology and Hematology summarizes important medical journal articles about a wide variety of oncology and hematology topics, including leukemia, anemia, lymphoma, thrombosis, and hemochromatosis.
